The a2Na /K-ATPase is critical for skeletal and heart muscle function in zebrafish
نویسندگان
چکیده
Canan Doğanlı, Kasper Kjaer-Sorensen, Christopher Knoeckel, Hans Christian Beck, Jens Randel Nyengaard, Bent Honoré, Poul Nissen, Angeles Ribera, Claus Oxvig and Karin Lykke-Hartmann* Centre for Membrane Pumps in Cells and Disease-PUMPKIN, Danish National Research Foundation, Department of Biomedicine, Aarhus University, Department of Molecular Biology and Genetics, Aarhus University, and Stereology and Electron Microscopy Laboratory, Center for Stochastic Geometry and Advanced Bioimaging, Aarhus University Hospital, DK-8000 Aarhus, Denmark Department of Physiology and Biophysics, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO 80045, USA Odense University Hospital, Department for Clinical Biochemistry and Pharmacology, Centre for Clinical Proteomics, DK-5000-Odense, Denmark
منابع مشابه
The α2Na+/K+-ATPase is critical for skeletal and heart muscle function in zebrafish.
The Na(+)/K(+)-ATPase generates ion gradients across the plasma membrane, essential for multiple cellular functions. In mammals, four different Na(+)/K(+)-ATPase α-subunit isoforms are associated with characteristic cell-type expression profiles and kinetics. We found the zebrafish α2Na(+)/K(+)-ATPase associated with striated muscles and that knockdown causes a significant depolarization of the...
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